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A six-month cynomolgus monkey study of two DAC-modified peptides concluded that they produced no evidence of immunogenic or immunotoxic effects — but FDA notes that the data description is vague, that the absence of neutralising antibodies appears to apply only to the other compound in that study, and that no assessment of plasma GH or IGF-1 was provided for the CJC-1295 DAC-treated monkeys to demonstrate that pharmacological activity even persisted through the dosing period [11]

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doi: 10.3390/nu15061518 [DOI] [PMC free article] [PubMed] [Google Scholar]